Surface antigens of melanoma and melanocytes. Specificity of induction of Ia antigens by human gamma-interferon.

Surface antigens of melanoma and melanocytes. Specificity of induction of Ia antigens by human gamma-interferon

IFN-gamma is known to induce expression of Ia antigens on a variety of cell types. In the present study, this activity of IFN-gamma has been analyzed with a panel of 36 melanoma cell lines, normal melanocytes, and 97 cell lines representing a range of other differentiation lineages. 55% of the melanoma cell lines express Ia antigens in a constitutive manner without IFN-gamma induction. Of the 1...

Induction of Ia Antigens on Synovial Cells by Gamma Interferon

Cell Surface Antigens of Human Melanocytes and Melanoma

Clinical and histopathological observations suggest that the pathogenesis of cutaneous melanoma evolves through multiple stages . It has been proposed that early stages are characterized by benign proliferation of melanocytic cells and later stages by acquisition of competence for invasion and metastasis (1) . The recognition that dysplastic nevi are a class of pigmented lesions with potential ...

Cell-surface antigens of melanoma recognized by human monoclonal antibodies.

Human monoclonal antibodies (mAbs) were derived from lymph node lymphocytes and peripheral blood lymphocytes (PBL) from patients with melanoma. Four methods for generating human mAbs were compared: fusion with human [LICR-LON-HMy-2 (LICR-2)] or mouse (NS-1) cells; transformation by Epstein-Barr virus (EBV); and EBV transformation followed by NS-1 fusion. NS-1 fusion with lymph node lymphocytes ...

Surface antigens of melanocytes and melanomas. Markers of melanocyte differentiation and melanoma subsets

The surface antigens of melanocytes from newborn and adult skin have been analyzed with monoclonal antibodies detecting cell surface antigens of malignant melanoma. Antigenic markers that distinguish early, intermediate, and mature stages in melanocyte differentiation have been defined. The characteristics of the normal melanocyte precursor have been inferred from the features of melanomas that...